![]() We retrospectively collected 244 and 177 patients with IHA and APA at baseline. We aimed to investigate the prevalence of metabolic syndrome (MetS) in each primary aldosteronism subtype and observe the role of KCNJ5 mutations among APAs on the distribution of abdominal adipose tissues quantified using computed tomography (CT), including their changes postadrenalectomy. Moreover, KCNJ5 mutations are prevalent among APAs and enhance aldosterone synthesis in adrenal cortex. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website ( ).Īldosterone overproduction and lipid metabolic disturbances between idiopathic hyperaldosteronism (IHA) and unilateral aldosterone-producing adenoma (APA) have been inconsistently linked in patients with primary aldosteronism. ![]() Supplemental digital content is available for this article. Tel: +886 2 23562570 fax: +886 2 23224552 e-mail: Ībbreviations: AGT, angiotensinogen APA, aldosterone-producing adenoma ARR, aldosterone–renin ratio AVS, adrenal venous sampling CT, computed tomography IHA, Idiopathic hyperaldosteronism MetS, metabolic syndrome PAC, plasma aldosterone concentration PSM, propensity score matching RAS, renin-angiotensin system SAT, subcutaneous adipose tissue TAIPAI, Taiwan Primary Aldosteronism Investigation VAT, visceral adipose tissue ![]() 7, Chung-Shan South Road, Taipei 100, Taiwan. GDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, TaiwanĬorrespondence to Chin-Chen Chang, Department of Medical Imaging, National Taiwan University Hospital, No. Program of Biomedical Science and Engineering, School of Biomedical Science and Engineering, National Yang Ming Chiao Tung UniversityĮDepartment of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of MedicineįDepartment and Graduate Institute of Forensic Medicine, National Taiwan University College of Medicine Program of Biomedical Science and Engineering, School of Biomedical Science and Engineering, National Yang-Ming UniversityĭIndustrial Ph.D. ADepartment of Biomedical Imaging and Radiological Sciences, National Yang-Ming UniversityīDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung UniversityĬIndustrial Ph.D.
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